Robust trend tests for genetic association in case-control studies using family data
نویسندگان
چکیده
منابع مشابه
Title Robust Tests for Case-control Genetic Association Studies
May 10, 2010 Type Package Title Robust tests for case-control genetic association studies Version 1.03 Date 2010-05-10 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. The te...
متن کاملTests for genetic association using family data.
We use likelihood-based score statistics to test for association between a disease and a diallelic polymorphism, based on data from arbitrary types of nuclear families. The Nonfounder statistic extends the transmission disequilibrium test (TDT) to accommodate affected and unaffected offspring, missing parental genotypes, phenotypes more general than qualitative traits, such as censored survival...
متن کاملComparison of robust tests for genetic association using case-control studies
In genetic studies of complex diseases, the underlying mode of inheritance is often not known. Thus, the most powerful test or other optimal procedure for one model, e.g. recessive, may be quite inefficient if another model, e.g. dominant, describes the inheritance process. Rather than choose among the procedures that are optimal for a particular model, it is preferable to see a method that has...
متن کاملOptimal Trend Tests for Genetic Association Studies of Heterogeneous Diseases
The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventiona...
متن کاملPackage 'rassoc' Title Robust Tests for Case-control Genetic Association Studies
November 6, 2009 Type Package Title Robust tests for case-control genetic association studies Version 1.01 Date 2009-11-06 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. T...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2005
ISSN: 1471-2156
DOI: 10.1186/1471-2156-6-s1-s107